Assessment of Prognostic Significance of Monosomy 7 in Myeloid Malignancies Sole or with Recurrent Chromosomal Abnormalities: An Indian Experience

Clonal disorders that are characterized by acquired somatic mutations in hematopoietic progenitors are generally observed in myeloid malignancies. Recent advances in understanding of the genetic basis of myeloid malignancies have provided important insights into the pathogenesis of Acute Myeloid Leukemia (AML) and Myeloproliferative Diseases (MPD) and have led to the development of novel therapeutic approaches. Monosomy 7 or partial deletion of the long arm of chromosome 7 (7q-) is a frequent cytogenetic finding in the bone marrow of patients with Myelodysplasia and AML being found in about 40% of patients. In contrast, -7 or deletion of the long arm of chromosome 7 [del(7q)] is found in only 4% to 5% of pediatric patients with AML. In this research article we are reporting 12 patients with monosomy 7 in hematologic malignancies. Total 12 patients were studied using conventional cytogenetic and Fluoresence in Situ Hybridization techniques. From 12 patients, 6 patients with AML diagnosis, 4 with Chronic Myelomonocytic Leukemia (CML) and 2 were with Juvenile Myelomonocytic Leukemia (JMML). Out of all 12 patients, 10 patients expired within 3-6 months of diagnosis. Based on our results, we concluded that monosomy 7 along with other cytogentic changes shows poor prognosis.

Keywords: 7/del7q, monosomy 7, deletion 7, FISH, Myeloid Leukemia.